- Some antiseptic and chemical agents have been shown to damage cells.
- The use of topical antiseptics may be beneficial for short term use, particularly when bacterial levels are sufficiently high to cause tissue destruction and the goal of care is the maintenance of the wound.
- Some antiseptics have been shown to be safe and efficacious for this purpose in wound care.
|
Antiseptic |
In-vitro studies support use |
In-vivo studies support use |
Requires more human trials to assess efficacy and safety |
Level of Evidence |
|
Acetic Acid 0.25% or 0.5% |
Yes |
Yes |
|
A |
|
Chlorhexadine 0.05% or 0.2% |
Yes |
Yes |
Yes |
|
|
Silver Compounds |
Yes |
Yes |
|
A |
|
Povidone Iodine |
Yes |
Yes |
Yes |
|
|
Cadexomer Iodine |
Yes |
Yes |
|
A |
|
Hydrogen Peroxide 3% Solution |
|
|
Yes |
|
Clinical Management
Assessment and Management of Venous Leg Ulcers
Point of Care Resources